Figure 1.
XIAP antagonists induce apoptosis of leukemia cell lines. Jurkat, OCI-M2, OCI-AML 2, and K562 leukemia cells (6.5 × 105/mL) were treated with increasing concentrations of the active XIAP antagonists 1396-12 (▪), 1396-22 (▴), 1396-34 (•), or the structurally related inactive control 1396-28 (○). At 24 hours after treatment, apoptosis was measured by annexin V staining (% positivity). The mean plus or minus SD of 3 independent experiments is shown.
