Figure 4.
Viral vectors have a profound effect on MLR. The functional consequence of viral transduction was tested in MLRs to evaluate the capacity of 104 DCs to stimulate 105 allogeneic T cells. DCs (either iDCs, ▪, or mDCs, □) were transduced with Ad, EIAV, HIV, or MMLV at the MOI indicated and then used as stimulators of allogeneic T cells in an MLR. 3H-thymidine incorporation was analyzed on day 5. The results are shown as the mean plus or minus SD. *P was less than .05 when ANOVA analysis and simple Student t test were carried out to compare multiple means and 2-pairing means, respectively.
