Primary cutaneous diffuse large B-cell lymphoma, leg type. (A) Clinical presentation with multiple tumors on right lower leg. (B) Monotonous proliferation of centroblasts and immunoblasts (H&E staining; original magnification,× 480). (C-D) Characteristically, the neoplastic B cells strongly express bcl-2 (C) and Mum-1/IRF-4 (D). Image acquisition for panels B-D was performed as described for Figure 1B. An HC Plan APO objective was used (40×/0.85 for panel B; 20×/0.70 for panels C and D).