Primary cutaneous follicle center lymphoma. (A) Typical presentation with tumors on the chest surrounded by less infiltrated erythematous skin lesions. (B) Presentation with multiple tumors confined to the scalp. (C) Diffuse dermal infiltrate mainly consisting of large centrocytes and multilobated cells (H&E staining; original magnification, × 480). (D-E) Serial sections stained for CD20 (D) and bcl-2 (E). Bcl-2 is expressed by perivascular T cells, but not by the neoplastic B cells. Image acquisition for panels A and C-E was performed as described for Figure 1B. An HC Plan APO objective was used (40×/0.85 for panel C; 10×/0.40 for panels D and E).