Primary cutaneous aggressive epidermotropic CD8⁺ cytotoxic T-cell lymphoma. (A) Typical presentation with nodules and tumors showing central ulceration. (B-D) Tumor cells show striking epidermotropism (H&E staining; original magnification, × 150), and strongly express CD8 (C) and TIA-1 (D). Image acquisition for panels B-D was performed as described for Figure 1B. An HC Plan APO 10×/0.40 objective lens was used.