Subcutaneous panniculitis-like T-cell lymphoma. (A) Deeply seated nodular skin lesions and residual lipodystrophy after disappearance of the skin lesions. (B) Infiltrates are almost exclusively localized in subcutaneous tissue resembling a lobular panniculitis (H&E staining; original magnification, × 25). (C) Rimming of individual fat cells by neoplastic T cells (H&E staining; original magnification, × 480). (D) Tumor cells show positive staining for CD8. Image acquisition for panels B-D was performed as described for Figure 1B. An HC FLUOTAR 2.5×/0.07 objective was used for panel B; an HC Plan APO 40×/0.85 objective was used for panels C and D.