Figure 5.
Figure 5. Induction of CLL cell death by 8-Cl-Ado. Several experimental approaches were used to determine cell death of primary leukemic lymphocytes by 8-Cl-Ado. Immunoblot analysis of cleavage of procaspase 3 to active caspase 3 (A), caspase activation detection by fluorescent assay (B), time-dependent cleavage of PARP (C), and apoptotic death measured by sub GO-G1 DNA content (D).

Induction of CLL cell death by 8-Cl-Ado. Several experimental approaches were used to determine cell death of primary leukemic lymphocytes by 8-Cl-Ado. Immunoblot analysis of cleavage of procaspase 3 to active caspase 3 (A), caspase activation detection by fluorescent assay (B), time-dependent cleavage of PARP (C), and apoptotic death measured by sub GO-G1 DNA content (D).

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