Figure 1.
Schematic diagram of annexin V and its fusion products with various Kunitz-type inhibitors. ANV indicates annexin V; TAP-ANV, Ala-tick anticoagulant peptide linked to annexin V by Gly-Ser dipeptide; ANV-6L15, annexin V linked to 6L15 (a Kunitz inhibitor derived from aprotinin with high affinity for TF/VIIa); ANV-KAPP, annexin V linked to KAPP (Kunitz inhibitory domain of amyloid β-protein precursor); ANV-KKTFPI, annexin V linked to KKTFPI (TFPI residues 22 to 161 containing Kunitz-1 and Kunitz-2 domains); C → A, Cys316Ala mutation in ANV; R → H, Arg2His mutation in 6L15.

Schematic diagram of annexin V and its fusion products with various Kunitz-type inhibitors. ANV indicates annexin V; TAP-ANV, Ala-tick anticoagulant peptide linked to annexin V by Gly-Ser dipeptide; ANV-6L15, annexin V linked to 6L15 (a Kunitz inhibitor derived from aprotinin with high affinity for TF/VIIa); ANV-KAPP, annexin V linked to KAPP (Kunitz inhibitory domain of amyloid β-protein precursor); ANV-KKTFPI, annexin V linked to KKTFPI (TFPI residues 22 to 161 containing Kunitz-1 and Kunitz-2 domains); C → A, Cys316Ala mutation in ANV; R → H, Arg2His mutation in 6L15.

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