American Society of Hematology

Figure 2.

$Figure 2. In vivo multilineage reconstitution by LSKCD34+flt3– and LSKCD34+flt3+ ST-HSCs. Lethally irradiated C57bl/6 CD45.1/CD45.2 mice were given transplants with 50 CD45.2 LSKCD34+flt3– (○) or LSKCD34+flt3+ (•) cells together with 200 000 CD45.1 unfractionated BM cells. Figure shows percent contribution to total PB cells of (A) total, (B) myeloid, (C) B-cell, and (D) T-cell reconstitution derived from transplanted LSKCD34+flt3– and LSKCD34+flt3+ cells 3, 5, 7, and 16 weeks after transplantation. All data represent the means (SEM) of 16 to 18 mice per group from 3 experiments.$

In vivo multilineage reconstitution by LSKCD34⁺flt3^– and LSKCD34⁺flt3⁺ ST-HSCs. Lethally irradiated C57bl/6 CD45.1/CD45.2 mice were given transplants with 50 CD45.2 LSKCD34⁺flt3^– (○) or LSKCD34⁺flt3⁺ (•) cells together with 200 000 CD45.1 unfractionated BM cells. Figure shows percent contribution to total PB cells of (A) total, (B) myeloid, (C) B-cell, and (D) T-cell reconstitution derived from transplanted LSKCD34⁺flt3^– and LSKCD34⁺flt3⁺ cells 3, 5, 7, and 16 weeks after transplantation. All data represent the means (SEM) of 16 to 18 mice per group from 3 experiments.

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