EDSS outcome. Box plot of the changes in EDSS score over the entire study period and in the year before the enrollment. Error bars indicate the highest and lowest values, excluding outliers (○), which are cases with values between 1.5 and 3 box lengths from the upper or lower edge of the box. Extremes (*) are cases with values more than 3 box lengths from the upper or lower edge of the box; the box length is the interquartile range.