MBMP treatment eliminated the inhibitor and allowed coagulation factor administration to be discontinued. On the left y-axis (▴), inhibitor titer (BU/mL) is shown over the course of apheresis procedures in a representative patient (patient 14). On the right y-axis (), the change in measured FVIII activity is shown over the course of apheresis procedures. The dose of administered FVIII IU × 1000 (filled arrow) and the time points of immunoglobulin substitution (open arrow) are marked. In this 68-year-old patient with a pretreatment inhibitor titer of 327 BU FVIII, the inhibitor was completely eliminated before the third treatment cycle (after the 14th apheresis session).