Continuous HRs and BPs of mice after LPS administration. In all panels, the solid line indicates WT mice (n = 10), and the broken line represents EPCR^δ/δ mice (n = 8). The arrow indicates the time of the implantation of the osmotic pumps. The statistical difference was indicated as ^* or ^#, P < .05 or P < .01, respectively. (A) HR in beats/minute (bpm); (B) systolic BP in mmHg; (C) diastolic BP in mmHg; and (D) pulse pressures in mmHg. Error bars indicate SEM.