C1INH suppressed the increase in microvascular permeability in mice in response to systemic administration of LPS. C57BL/6J mice were injected with LPS (20 μg/kg per mouse, intraperitoneally) in the absence of C1INH (n = 6; 200 μg per mouse, intravenously). Control mice were injected with PBS (n = 6). The microvascular endothelial permeability index in the lungs (A), heart (B), liver (C), and intestine (D) were determined, respectively.