Figure 6.
Figure 6. C1INH-deficient mice are more susceptible to local subcutaneous injection of LPS. C1INH-/- or C1INH+/+ littermate mice were given subcutaneous injections of LPS, with or without C1INH, in the abdominal skin. (A) C1INH-/- (right) and wild-type littermate (left) mice were injected subcutaneously with LPS (5 or 10 μg), either alone or following intravenous C1INH (200 and 400 μg). Control mice were injected with PBS alone. The numbers of mice in each experimental group were as indicated in the figure. (B) Photographs of the abdominal skin of the wild-type littermate (top) and the C1INH-/- mice (bottom) showing the leakage of the dye at the site of subcutaneous injection of LPS and its inhibition when the mouse was treated with intravenous C1INH. Experimental data were presented as means ± standard deviations using GraphPad Prism 3.0 software.

C1INH-deficient mice are more susceptible to local subcutaneous injection of LPS. C1INH-/- or C1INH+/+ littermate mice were given subcutaneous injections of LPS, with or without C1INH, in the abdominal skin. (A) C1INH-/- (right) and wild-type littermate (left) mice were injected subcutaneously with LPS (5 or 10 μg), either alone or following intravenous C1INH (200 and 400 μg). Control mice were injected with PBS alone. The numbers of mice in each experimental group were as indicated in the figure. (B) Photographs of the abdominal skin of the wild-type littermate (top) and the C1INH-/- mice (bottom) showing the leakage of the dye at the site of subcutaneous injection of LPS and its inhibition when the mouse was treated with intravenous C1INH. Experimental data were presented as means ± standard deviations using GraphPad Prism 3.0 software.

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