Figure 2.
![Figure 2. RNAi-induced down-regulation of FLT3 sensitizes Ba/F3 FLT3-ITD transfectants and Molm-14 cells to treatment with MLN518. (A) Dose-dependent decrease in cell proliferation following treatment with decreasing concentrations of FLT3 siRNA (Ba/F3 FLT3-ITD cells [n = 8] and Molm-14 cells [n = 5]). (B) Treating Ba/F3 FLT3-ITD cells (n = 8) and Molm-14 cells (n = 5) with FLT3 siRNA increases their sensitivity to treatment with the FLT3 inhibitor MLN518. Error bars indicate standard deviation.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/105/7/10.1182_blood-2004-07-2758/6/zh80070576530002.jpeg?Expires=1724257715&Signature=1gWbPGEkC-XHu~grntPzPZ6SjlKW1pzecLQMrL2ogB2khqw9f~YHUvXWT2-0gbY3KZLgOllVJ2~XnL6IEgCDZax-O7FeeHIeL25cGyNxg2cXAYcSOe27KzBHCVw82oK6PqY5dfCV8sjE-4x3sLZFS4VMpJJc4zlljsihJqU6Z3vaMZAMdy0aFQpzVoqgeYtBuM~S6yZXCp5Gr702MFl1ATo8mnQo-NekAzJB2xRuG9L3s-AAnmTbEe4y-yNtfnpkvAwzw3dHW8nArDZ977D-XV~j0MRPZNv89T51cfwh0SDWC6XbUrm-nYc-CVKW8buMuyDhHdKa2whkz69aihAvFg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
RNAi-induced down-regulation of FLT3 sensitizes Ba/F3 FLT3-ITD transfectants and Molm-14 cells to treatment with MLN518. (A) Dose-dependent decrease in cell proliferation following treatment with decreasing concentrations of FLT3 siRNA (Ba/F3 FLT3-ITD cells [n = 8] and Molm-14 cells [n = 5]). (B) Treating Ba/F3 FLT3-ITD cells (n = 8) and Molm-14 cells (n = 5) with FLT3 siRNA increases their sensitivity to treatment with the FLT3 inhibitor MLN518. Error bars indicate standard deviation.
