Figure 3.
Figure 3. KIR genotypes for the human NK cells used in functional studies . / KIR genotyping was performed on the donor-derived blood cells used in the functional studies (see “Materials and methods”). Dark boxes indicate the presence of a KIR gene and white boxes their absence. KIR3DL1 allele typing for donors 35 and 43 is also shown. . / *Donors were coded numerically. . / †Inhibitory KIR genes (2DL1-5 and 3DL1-2) encode for class I receptors with long cytoplasmic tails containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs).16 Despite possessing a long cytoplasmic tail with ITIMs, KIR2DL4 has potential for both inhibitory and stimulatory function.46-49 . / ‡Stimulatory KIR genes (2DS1-5 and 3DS1) encode receptors with short cytoplasmic tails that lack ITIMs. . / §ELISPOT (∥) or ICS (¶) analyses were used to determine the proportion of NK cells inhibited by the indicated class I allotypes.

KIR genotypes for the human NK cells used in functional studies

KIR genotyping was performed on the donor-derived blood cells used in the functional studies (see “Materials and methods”). Dark boxes indicate the presence of a KIR gene and white boxes their absence. KIR3DL1 allele typing for donors 35 and 43 is also shown.

*Donors were coded numerically.

†Inhibitory KIR genes (2DL1-5 and 3DL1-2) encode for class I receptors with long cytoplasmic tails containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs).16  Despite possessing a long cytoplasmic tail with ITIMs, KIR2DL4 has potential for both inhibitory and stimulatory function.46-49 

‡Stimulatory KIR genes (2DS1-5 and 3DS1) encode receptors with short cytoplasmic tails that lack ITIMs.

§ELISPOT (∥) or ICS (¶) analyses were used to determine the proportion of NK cells inhibited by the indicated class I allotypes.

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