Figure 7.
Figure 7. uPAR84-95 increases the output of clonogenic progenitors in LTCs. The output of myeloid and erythroid colony-forming cells (CFCs), generated from LTCs of highly purified BM CD34+ cells, was measured by replating nonadherent cells in methylcellulose. Nonadherent cells were removed weekly after 2-hour LTC treatment with the uPAR84-95 (▪) peptide or its scrambled version (). Each value represents the mean ± SD of CFCs obtained from 3 independent experiments performed in duplicate.

uPAR84-95 increases the output of clonogenic progenitors in LTCs. The output of myeloid and erythroid colony-forming cells (CFCs), generated from LTCs of highly purified BM CD34+ cells, was measured by replating nonadherent cells in methylcellulose. Nonadherent cells were removed weekly after 2-hour LTC treatment with the uPAR84-95 (▪) peptide or its scrambled version (). Each value represents the mean ± SD of CFCs obtained from 3 independent experiments performed in duplicate.

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