The rapid reticulocyte γ-globin response. (A-B) Kinetics in a representative patient with SCD responsive to butyrate: γ-globin protein chain synthesis (A) and γ-globin mRNA (B). (C-D) Reticulocyte γ-globin protein chain synthesis (C) and γ-globin mRNA (D), respectively, in 5 patients responsive to butyrate (○, ▵, □, ×, ⋄) and 2 patients not responsive to butyrate (+,-)(•). Mean ± 1 SD.