Immunohistochemistry for hCNT3 in pancreas tissue and lymph nodes from CLL patients. (A) Normal pancreas tissue showing the intense positive cytoplasmic staining for hCNT3 exhibited by pancreatic islet cells (original magnification × 25; inset × 40). (B) This CLL case shows pseudofollicles with prolymphocytes (white arrows) that were positive for hCNT3 immunostaining, whereas the small cell component (black open arrow) shows no immunostaining (original magnification × 40). (C) This CLL case again shows cytoplasmic staining in the scattered prolymphocytes, whereas small cells show detectable cytoplasmic immunostaining (original magnification × 40). Images were captured with a Nikon Eclipse E 680 microscope by Nikon View V3.0 software (Nikon, Melville, NY) using a Nikon 40 × lens with a 0.65 aperture.