Time to disease progression dichotomized by hCNT3 expression. Kaplan-Meier analysis demonstrates that those patients with a high hCNT3 expression of at least 0.4 (arbitrary PCR units, - - -) had a substantially shorter time to disease progression after fludarabine therapy compared with those with levels less than 0.4 (arbitrary PCR units, —). The difference is significant with a hazard ratio of 4.67 (adjusted; P = .0007).