Cytokine stimulation. Experimental data (mean ± SD) of (A) rhFlt3-ligand and (B) rhG-CSF stimulation of stabilized (day 290 after transplantation) primary radiation chimeras. (C) Corresponding average simulation result of cytokine stimulation (no difference assumed for rhFlt-3-ligand and rhG-CSF effects). In all panels, the upper graphics show the chimerism development, with gray bars representing the period of cytokine stimulation. The lower graphics show white blood cell counts at day 7, 14, and 21 after the start of treatment, relative to pretreatment levels.