Effect of anti-CXCR1 and anti-CXCR2 antibodies on the ploidy distribution of CD41⁺ MK cells derived from normal or MMM CD34⁺ cell culture. Polyploidy was evaluated by flow cytometry analysis, at days 12 to 14 of culture, on CD41⁺ MK cells grown in either the absence or the presence of anti-CXCR1 and anti-CXCR2 antibodies (10 μg/mL). CD41⁺ MK cells were stained with PI as described in “Materials and methods.” Histograms show the DNA content of CD41⁺ MK cells derived from normal (panel A) and MMM CD34⁺ (panel B) cells. One representative experiment from 3 separate experiments is shown for NPB. patients with MMM were individually analyzed.