Figure 1.
The IKK2 inhibitor AS602868 induces apoptosis of AML blasts. (A) Cells from patient 2 (36% CD34+ blasts) were incubated for 72 hours with indicated doses of AS602868 and VP16 before staining with anti-CD34-FITC antibody and annexin V-PE. Cells were gated on the CD34+ compartment. The percentages of apoptotic cells are displayed. (B) Sub-G1 analysis of apoptotic blasts. Blasts from patient 11 (more than 90% blasts) were stained with propidium iodide. The percentage of apoptotic blasts in sub-G1 (gate M3) is displayed.
