Summary of interferon-inducible gene response to injection of 1018 ISS. Data are expressed as fold induction after 1018 ISS compared with the matching pre–1018 ISS value. Significance of the differences among groups was analyzed by the Kruskal-Wallis test, with the following values: MCP-1, P = .005; MCP-2, P = .016; ISG54k, P = .024; 2'-5' OAS, P = .033; all other genes, P > .05. Comparisons of the 0.01 and the 0.5 mg/kg groups by Dunn posttest are indicated, if significant, on the figure. **P < .01; *P < .05.