Mean genetic distances within the HVR1 between early and late clonal sets for progressors and nonprogressors. Distance was calculated via the mean Kimura 2-parameter pairwise distances for each patient. Regardless of HIV status, progressors as a group tended to have greater genetic diversity at the early time point than nonprogressors (P = .04) and demonstrated significant narrowing of genetic diversity over time (P = .04). Nonprogressors as a group maintained the same level of diversity over the study duration.