In vivo activity of the agonist minibody sc(Fv)2 in cynomolgus monkeys. VB22B sc(Fv)2 (1.9 nmol/kg) or vehicle were administered daily by subcutaneous injection for 14 days (left panel). rhTPO (0.11 nmol/kg) or vehicle were administered daily by intravenous injection for 14 days (right panel). Peripheral platelet numbers were plotted. Standard deviations are represented by error bars.