Figure 1.
Figure 1. Normal fetal and bone marrow myelopoiesis but enhanced splenic myelopoiesis in 4- and 16-week-old Lyn-/- mice. Progenitors responsive to GM-CSF, IL-3, or M-CSF in the spleen and BM of (A) 16-week-old or (B) 4-week-old sex-matched Lyn+/+ and Lyn-/- mice were assessed by in vitro semisolid agar assays. Data presented in panels A-B correspond to the mean (± SEM) for 2 to 4 experiments using 2 to 3 mice per experiment. (C) Day-14 myeloid fetal liver progenitor populations in Lyn+/+ (n = 9), Lyn+/- (n = 17), or Lyn-/- (n = 8) mice were assessed in the presence of the indicated cytokines (mean ± SEM). Fetal livers were derived from day-14 embryos obtained from time-mated Lyn+/- mice. The splenic myeloid data presented in panel A (left panel) have been reported previously22 (reprinted from Immunity, Vol 15, Harder KW, Parsons LM, Armes J, et al, “Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage,” pages 603-615, copyright (2001), with permission from Elsevier).

Normal fetal and bone marrow myelopoiesis but enhanced splenic myelopoiesis in 4- and 16-week-old Lyn-/- mice. Progenitors responsive to GM-CSF, IL-3, or M-CSF in the spleen and BM of (A) 16-week-old or (B) 4-week-old sex-matched Lyn+/+ and Lyn-/- mice were assessed by in vitro semisolid agar assays. Data presented in panels A-B correspond to the mean (± SEM) for 2 to 4 experiments using 2 to 3 mice per experiment. (C) Day-14 myeloid fetal liver progenitor populations in Lyn+/+ (n = 9), Lyn+/- (n = 17), or Lyn-/- (n = 8) mice were assessed in the presence of the indicated cytokines (mean ± SEM). Fetal livers were derived from day-14 embryos obtained from time-mated Lyn+/- mice. The splenic myeloid data presented in panel A (left panel) have been reported previously22  (reprinted from

Immunity, Vol 15, Harder KW, Parsons LM, Armes J, et al, “Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage,” pages 603-615, copyright (2001)
, with permission from Elsevier).

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