Telomere maintenance in Fancg^-/- hematopoietic cells. (A) Telomere restriction fragments of BMCs and concanavalin A-stimulated splenocytes. Note the absence of telomeric signals below 10 kbp and similar TRF distribution in all genotypes. (B) Comparative telomere length of G₀/G₁ hematopoietic cells by flow-FISH analysis. Mean and standard deviation of results from 2 mice per group are shown. (C) Comparison of telomere length average and distribution of Fancg^-/- BMCs and splenocytes and their Fancg^+/- littermates. Ten metaphases per mouse were analyzed after hybridization with a Cy3-labeled telomere-specific PNA probe.