Expression signature of core-binding factor AMLs. Two-dimensional hierarchical clustering of the 130 AML cases using the top 50–ranked discriminating probe sets for the core-binding factor (CBF) leukemias (AML1-ETO and CBFβ-MYH11 cases). The genetic subtype of each case is presented by a color-coded bar at the bottom of the figure, using the same color scheme used in Figures 1, 2, 3. The probe set number and gene symbol for the discriminating genes are listed on the right. The normalized expression level for each gene is represented by a color using the scale shown in the lower left corner. Cases were clustered using a cosine function.