Migratory defects in multiple WASp-deficient lineages. Multiple cell lineages, including stem cells, megakaryocytes, lymphocytes, and myeloid cells, have been shown to exhibit migratory deficiency either in vitro or in vivo. Together, these data indicate the importance of WASp for normal cell motility and suggest that dysregulated trafficking may be a major contributor to the pathogenesis of WASp-related human disease. Arrows depict transport through blood vessels unless otherwise indicated.