Figure 3.
![Figure 3. Inhibition of choline uptake by novel antimalarials. (A) Concentration-dependent inhibition by T16 of [3H]-choline (15 μM) uptake into isolated P falciparum parasites over 10 minutes at 22°C. Data are mean ± SD for duplicate observations from 3 individual experiments. (B) Lineweaver-Burke (double reciprocal) plot of choline uptake as a function of external choline concentration into isolated P falciparum parasites over 10 minutes at 22°C. Data are presented for choline alone (○) or choline in the presence of 10 μM pentamidine (•). Data are mean ± SD for duplicate observations from 3 individual experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/104/10/10.1182_blood-2004-03-1084/6/zh80220469140003.jpeg?Expires=1725312728&Signature=vKXqeN~5OFQpRraCokUc4NvALQ9gSOxQg0MvNnQm3fSG7JTHbJSzlnrqLvnJOKQSrljvmJLXRbO8ksa7C8yjy4XrlcitDP8I9kN44opUeK8s2Pedvr68XsGbI8I5RvuhXhWzTfqqmVwYvTcgo1MGibMdHRFBddzPDa1qM5XSgC9iBtGbF7PYV5k2McS3LzWo~fBWrDLlDs8tswm~KJRiGZEqN~un4r154G0yU7SX5rgjmxw3z3S1WG1inScrvPhBMqVqYdUSuXgIrzkgU6V73OLdrS1h1p1-N5W3y46WLNRTEhCbZISu3EsXimDQm6beWAwg1A6Kkkl8qup4LZZq8A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of choline uptake by novel antimalarials. (A) Concentration-dependent inhibition by T16 of [3H]-choline (15 μM) uptake into isolated P falciparum parasites over 10 minutes at 22°C. Data are mean ± SD for duplicate observations from 3 individual experiments. (B) Lineweaver-Burke (double reciprocal) plot of choline uptake as a function of external choline concentration into isolated P falciparum parasites over 10 minutes at 22°C. Data are presented for choline alone (○) or choline in the presence of 10 μM pentamidine (•). Data are mean ± SD for duplicate observations from 3 individual experiments.
