Positions of c-myc, IgH, Igκ, or Igλ breakpoints in t(8;14), t(2;8), or t(8;22) Burkitt lymphoma. The breakpoints for t(8;14) in endemic BL (eBL), sporadic BL (sBL), and immunodeficiency BL (HIV BL) are depicted. Juxtaposition of the Eμ enhancer on the IgH gene of chromosome 14, Ei and E3′ enhancers in the κ locus of chromosome 2, and HuEλ enhancer in the λ locus of chromosome 22 with the c-myc gene on chromosome 8 drive c-Myc overexpression in BL with t(8;14), t(2;8), and t(8;22), respectively.