Figure 2.
Alignment of amino acid sequences in groups with restricted HCDR3s. Alignment of amino acid sequences from the VH gene and VL gene rearrangements in the 3 groups with highly restricted HCDR3s (the VH3-21 alignment has been published elsewhere18 ; A) and the 3 groups with moderate HCDR3 restriction (B). The VH gene rearrangements sequences are shown to the left and the VL sequences to the right. A dot indicates homology with the top sequence. The CDR1, CDR2, and CDR3 are indicated. The D gene segment and the start of the JH/JL genes are underlined. In CLL27, the third amino acid in the HCDR3 is underlined, as it is part of the D3-16 gene. ND indicates that the rearrangement was not determined; and *, position with allelic variants.
