Effects of MLN518 on leukocyte recovery after stem cell transplantation. (A) After lethal irradiation, Balb/c mice received transplants with 5 × 105 bone marrow MNCs with (▪) or without (□) concomitant administration of 180 mg/kg MLN518 twice daily. Significant differences were observed on day 28 (P < .05). (B) Three-part differential count for lymphocytes, monocytes, and granulocytes for MLN518 treatment group (solid symbols) and the carrier (open symbols). (C) Lethally irradiated mice received transplants with 1 × 106 mononuclear bone marrow cells from primary recipients. Compared with the primary transplants, there was delayed recovery of the WBC count. No difference was observed between mice that received transplants with marrow from MLN518-treated mice and controls (P > .1, Student t test for all time points). Data represent the mean ± standard deviation.
