The effects of MLN518 on steady-state WBC counts. Balb/c mice were treated with a daily dose of 180 mg/kg MLN518 twice daily (▪) or carrier (□) for 21 days. WBC counts were compared with their pretreatment values (day 0). Significant differences were only observed on day 11 (P < .05, Student t test). Data represent the mean ± standard deviation.