Restricted D segment and JH gene use by the 163 CLL B-cell cases that express unmutated Ig heavy chains encoded by 51p1. (A) Relative expression of the most common D segments used by the 51p1-encoded heavy chains expressed in this cohort. Values are expressed as a percentage of the 163 samples found to use each of the different D segments. Some of the D segments found to be frequently used by the heavy chains analyzed in this cohort also display a restricted use of certain reading frames (RF), as indicated by the distribution of RF used for D2-2. (B) Relative expression of the JH genes used by the 51p1-encoded heavy chains expressed in this cohort. Values are expressed as a percentage of the 163 samples found to use genes from each of the JH families.
