Figure 1.
Figure 1. In vitro drug resistance in 275 children with precursor B-ALL positive or negative for ETV6/RUNX1 (TEL/AML1) gene fusion. ETV6/RUNX1+ patients were significantly more sensitive to (A) doxorubicin (P = .003), (B) dexamethasone (P = .043), and (C) etoposide (P = .001), but were more resistant to (D) cytarabine (P = .016). The box-and-whisker plot shows median, first, and third quartiles; whiskers extend to the highest and lowest value, excluding outliers, which are denoted by circles.

In vitro drug resistance in 275 children with precursor B-ALL positive or negative for ETV6/RUNX1 (TEL/AML1) gene fusion. ETV6/RUNX1+ patients were significantly more sensitive to (A) doxorubicin (P = .003), (B) dexamethasone (P = .043), and (C) etoposide (P = .001), but were more resistant to (D) cytarabine (P = .016). The box-and-whisker plot shows median, first, and third quartiles; whiskers extend to the highest and lowest value, excluding outliers, which are denoted by circles.

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