Multivariate analysis assessed by multiple correspondence analysis: profiles of patients with hypodiploidy with 30 to 39 chromosomes and near-triploidy. Multiple correspondence analysis or dual scaling represents a qualitative analysis and provides an image of karyotype profiles23 in a less-dimensioned space defined by the factorial axis (factors). Different profiles can be plotted on the same graphic. This multivariate analysis takes into account different levels (interaction). As in component analyses, the distance of a modality from the center of gravity of the cluster reflects the rarity of the corresponding event in the population. The intensity of the association of 2 profiles is inversely proportional to the distance between 2 plots. First the profile for each chromosome (chromosome 1, chromosome 2,..., chromosome 22) was plotted on the same graph according to its monosomic (× 1), or disomic (× 2), or trisomic or tetrasomic (× 3 or × 4) status. Each symbol results from the analysis of the 24 patients. ▪, the profile of < 2n chromosome (monosomic); *, the profile of > 2n chromosomes (trisomic or tetrasomic); ▴, the profile of a diploid chromosomes (2n) (disomic). Neither the number of the chromosome nor the patients they belong to are specified. Then each patient was plotted summarizing the dots that correspond to each of his 22 autosomes as defined (▪ or * or ▴). Each symbol (•) on the graph represents the profile of one patient. Then the points H and NT were plotted. H summarizes the profile of patients (•) with hypodiploidy with 30 to 39 chromosomes. NT summarizes the profile of patients (•) with near-triploidy. The proximity of H and NT indicates their closely associated profiles.
