Differences in expression of genes associated with T-cell activation between circulating and IVS immunization-induced T cells and between immunization-induced and concomitant CD8⁺ T cells induced by IVS. (A) Unpaired, two-tailed Student t test (P₂ < .05) was applied to select genes differentially expressed between circulating immunization-induced T cells in 3 patients and 5 IVS-induced immunization-specific samples. (B) Genes differentially expressed between 5 209-2M tHLA⁺ and tHLA^– subsets of CD8⁺ T cells from the same IVS cultures. Color coding is identical for both panels and represents, respectively, genes associated with effector function (red bars), relevant receptors (green bars), and genes associated with cell cycle regulation (blue bars).