Influence of humoral immunity on decreasing viral set points. Patients were stratified according to their ability to improve viremia control upon STI (n = 46). White squares depict patients who decreased viremia by more than 0.5 logs upon STI. Gray squares depict patients who did not reach a 0.5 log improvement of viremia. Horizontal bars indicate mean values. (A) Viral loads before ART and after STI are depicted. Anti-gp120 (B) and anti-p24 (C) titers at baseline (weeks 0 to 2) and maximum increases in titers reached during the trial are shown. Antibody reactivities and viral loads of the individual groups were compared using the unpaired t test. (A-C) All significant observations were significant on the individual level and also after Bonferroni correction.