American Society of Hematology

Figure 7.

$TVBT and volume of shed blood. (A) TVBTs. WT and Akt-1 null mice were anesthetized and tails were amputated at a position where the diameter of the tail was 2.5 mm and immersed in saline. The time from the incision to cessation of bleeding was recorded. Shown is the fraction of tails that are bleeding as a function of time after tail transection. Genotypes and the number of mice of each genotype are indicated. The effect of Akt-1 deficiency on bleeding time was significant by log-rank test (P = .035). (B) Volume of shed blood. The amounts of shed blood during bleeding time test were measured. Bars represent the means ± SE for 12 WT mice and 12 Akt-1 null mice. *Significantly greater amount of shed blood in Akt-1 null mice compared with WT mice (P < .05).$

TVBT and volume of shed blood. (A) TVBTs. WT and Akt-1 null mice were anesthetized and tails were amputated at a position where the diameter of the tail was 2.5 mm and immersed in saline. The time from the incision to cessation of bleeding was recorded. Shown is the fraction of tails that are bleeding as a function of time after tail transection. Genotypes and the number of mice of each genotype are indicated. The effect of Akt-1 deficiency on bleeding time was significant by log-rank test (P = .035). (B) Volume of shed blood. The amounts of shed blood during bleeding time test were measured. Bars represent the means ± SE for 12 WT mice and 12 Akt-1 null mice. ^*Significantly greater amount of shed blood in Akt-1 null mice compared with WT mice (P < .05).

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