Detectable TG1042-derived IFN-γ messages following the first and second treatment cycles. Changes in expression of TG1042-derived IFN-γ and natural IFN-γ at baseline and after TG1042 injections (A). Results are presented as GAPDH-normalized ratios. IFN-γ production pertinent to CD8 and CD4 T cells assessed by the IFN-γ mRNA to CD8 and CD4 ratio, respectively (plotted on the left y-axis), at baseline and after TG1042 injections (B). The changes in CD4/CD8 ratio are plotted against the right y-axis. Number of injections follows the patient number (eg, no. 001_3).