CEP-701 is more cytotoxic to primary pediatric AML blasts with FLT3/ITD mutations than those with FLT3/PM or FLT3/WT. (A) Dose-response curves showing mean cytotoxic response to CEP-701 for all assayed samples, grouped by FLT3 mutation status, normalized to untreated controls. Error bars represent standard error of the mean (SEM). (B) Dot plot of individual samples' cytotoxic response (mean of triplicate experiments) to CEP-701 at the 100-nM dose level, grouped by FLT3 mutation status. Error bars show the group mean ± SEM. P values are from Student t test. The dotted line represents the mean cytotoxic response of the entire sample set (60% of untreated control).