Concordance of protein levels and gene expression for 2 purine genes discriminating TEL-AML1–positive and TEL-AML1–negative ALL cells. FHIT and NME1 protein levels in whole cell lysates of 2 TEL-AML1–positive ALL and 3 TEL-AML1–negative ALL samples (from left to right, 2 hyperdiploid B-lineage and 1 B-lineage ALL with no defined genetic subtype) assessed by Western blotting. FHIT protein level was significantly higher and NME1 was significantly lower in TEL-AML1–positive ALL, which is concordant with the mRNA expression in these 2 groups.