The effects of specific ferrous ion chelators on NTBI uptake. Hepatocytes from Hfe KO (filled symbols) and control (open symbols) mice were incubated with ⁵⁹Fe-citrate (ratio of 1 μM Fe to 100 μM citrate) in the presence of 0 to 1000 μM BPS (A) and BP (B) for 1 hour at 37° C. Internalized (•, ○) and membrane (▪, □) uptakes are shown. Results are expressed as mean ± SD (n = 3). This graph is a typical representation from 2 independent experiments performed.