Schematic of possible effectors downstream of the P2Y₁₂ receptor. The figure depicts the signaling events that occur on ADP-induced P2Y₁₂ receptor stimulation. PI3-kinase γ, Akt, and Rap 1b are known effectors, which contribute to P2Y₁₂ receptor–mediated GPIIb/IIIa activation. The βγ subunit of the G_i released on receptor stimulation binds to and activates GIRK channels. GIRK channel activation results in the efflux of K⁺ and in the generation of an intracellular signaling cascade leading to integrin activation. Functional transducers mediating this signal are yet to be identified.