American Society of Hematology

Figure 3.

$Figure 3. Effect of patient C anti-EPCR autoantibody on kinetic parameters of APC generation by endothelial cells. Thrombin-catalyzed protein C activation on EA.hy926 cells measured in the absence (•) or presence (○) of patient C IgM fraction at 45 μg/mL. The Km for each condition is indicated. The Lineweaver-Burk plot in the inset shows that the Vmax in both conditions is essentially equal.$

Effect of patient C anti-EPCR autoantibody on kinetic parameters of APC generation by endothelial cells. Thrombin-catalyzed protein C activation on EA.hy926 cells measured in the absence (•) or presence (○) of patient C IgM fraction at 45 μg/mL. The K_m for each condition is indicated. The Lineweaver-Burk plot in the inset shows that the V_max in both conditions is essentially equal.

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