American Society of Hematology

Figure 2.

$Figure 2. Effect of anti-EPCR antibodies on APC generation by endothelial cells. Confluent EA.hy926 cells were incubated with buffer or the indicated Ab (RCR-252 at 20 μg/mL, the different patients' fractions at 45 μg/mL except indicated) and the initial rate (Vo) of thrombin-dependent activation of 50 nM PC was determined. For each condition, 2 to 4 independent experiments were performed. The mean ± standard deviation of %Vo with respect to the Vo obtained in the absence of antibodies is represented. *P = .013, ** P = .02, with respect to the buffer condition.$

Effect of anti-EPCR antibodies on APC generation by endothelial cells. Confluent EA.hy926 cells were incubated with buffer or the indicated Ab (RCR-252 at 20 μg/mL, the different patients' fractions at 45 μg/mL except indicated) and the initial rate (Vo) of thrombin-dependent activation of 50 nM PC was determined. For each condition, 2 to 4 independent experiments were performed. The mean ± standard deviation of %Vo with respect to the Vo obtained in the absence of antibodies is represented. *P = .013, ** P = .02, with respect to the buffer condition.

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