Cumulative incidence of severe acute GvHD (grade III/IV) in relation to NOD2/CARD15 SNPs. R indicates recipient; D: donor; R&D wt: unmutated (wildtype) SNPs in both R and D (n = 119); R mut/D wt: mutated SNPs in recipients only (n = 22); R wt/D mut: mutated SNPs in donors only (n = 16); R&D mut: mutated SNPs in donors and recipients (n = 12). Overall, differences were highly significant: P=.001 for the whole group; P=.07 for R mut D wt; P=.004 for R wt/D mut, and P=.001 for R&D mut if compared with unmutated R&D.