Figure 6.
Figure 6. Stimulated platelets express the huMab VN18 epitope after stimulation. Isolated platelets were not stimulated (A-B) or stimulated with ADP (50 μM; C-D) or thrombin (0.5 U/mL; E-F). Stimulation of platelets was monitored using the activation marker P-selectin, expressed as fluorescent signal on the x-axis. Binding of control huMab (10 μg/mL; A, C, E) or huMab VN18 (10 μg/mL; B, D, F) was expressed as fluorescent signal on the y-axis. The percentage of platelets localized in the rectangles of the plots is shown.

Stimulated platelets express the huMab VN18 epitope after stimulation. Isolated platelets were not stimulated (A-B) or stimulated with ADP (50 μM; C-D) or thrombin (0.5 U/mL; E-F). Stimulation of platelets was monitored using the activation marker P-selectin, expressed as fluorescent signal on the x-axis. Binding of control huMab (10 μg/mL; A, C, E) or huMab VN18 (10 μg/mL; B, D, F) was expressed as fluorescent signal on the y-axis. The percentage of platelets localized in the rectangles of the plots is shown.

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